Tag: Gene

  • What Is Hantavirus, the Rare Disease That Killed Betsy Arakawa?

    What Is Hantavirus, the Rare Disease That Killed Betsy Arakawa?


    Betsy Arakawa, the wife of Gene Hackman, died from the effects of hantavirus, a rare disease often caused by contact with droppings from infected rodents.

    Hantavirus does not spread among people in the cases found in the United States. It can be transmitted through rodent saliva. But it is most commonly transmitted by breathing in particles of dried deer mouse droppings or urine.

    At first, hantavirus causes flulike symptoms, including fever, chills, body aches and headaches. But as the disease progresses, respiratory symptoms develop and patients can experience shortness of breath and then lung or heart failure.

    Here is what to know about hantavirus.

    Hantavirus refers to a family of viruses that are carried by rodents. It is often transmitted to humans by inhaling particles from dried mouse droppings. In North America, Sin Nombre virus is the most common form of this virus, said Sabra L. Klein, a professor at the Johns Hopkins Bloomberg School of Public Health.

    As of the end of 2022, 864 cases of hantavirus disease had been reported in the United States since surveys of such cases began in 1993, according to the Centers for Disease Control and Prevention. The “classic” case of hantavirus is contracted by someone who has visited a rural cabin that has a rodent infestation, said Emily Abdoler, a doctor and assistant professor of medicine at the University of Michigan Medical School.

    Hantavirus can cause flulike symptoms that appear one to eight weeks after exposure to droppings from an infected rodent, according to Dr. Heather Jarrell, New Mexico’s chief medical examiner. Later, patients often experience shortness of breath and then lung or heart failure.

    The mortality rate from the hantavirus strain in the southwestern United States is between 38 and 50 percent, Dr. Jarrell said. The strain in the region cannot be transmitted from person to person, she said.

    In the United States, hantavirus is most commonly found in the Four Corners region — Utah, Colorado, Arizona and New Mexico — according to Dr. Abdoler.

    New Mexico has recorded from one to seven hantavirus infections each year for the past five years, according to Dr. Erin Phipps, a veterinarian at the New Mexico Department of Health.

    Most people get infected around their home or workplace, she said. On the property east of Santa Fe where Mr. Hackman and Ms. Arakawa lived, health officials found signs of rodent entry in some structures, although little risk of exposure to the virus in the main residence.

    It is not clear when Ms. Arakawa began to feel ill, Dr. Jarrell said.

    Although there are antivirals that can help manage symptoms, there are no cures specifically for hantavirus, Ms. Klein of Johns Hopkins said. That’s why prevention is important.

    If you live in an area where hantavirus-infected rodents are known to roam, clean any droppings with a wet paper towel. Do not use a vacuum or a broom, which can stir up the aerosols from the excrement.

    Use gloves and a tightfitting N95 mask in a well-ventilated space. People should spray the area with a bleach solution or a commercial disinfectant and let it sit for five minutes. Then they should clean the area with paper towels, tossing them in a trash can that closes tightly, Dr. Phipps said.

    Treatment of hantavirus in the intensive care unit may include intubation and oxygen therapy, fluid replacement and medications to support blood pressure. Sometimes antiviral drugs are used.

    Gina Kolata contributed reporting.



    Source link

  • Jake Heggie’s Adaptation of ‘Moby Dick’ Comes to the Metropolitan Opera

    Jake Heggie’s Adaptation of ‘Moby Dick’ Comes to the Metropolitan Opera


    When “Moby Dick” opens at the Metropolitan Opera this week, audiences will experience a deeply American story of unchecked ambition, fomented grievances and a self-destructive desire for revenge.

    Based on Herman Melville’s 1851 novel, the opera delivers an economical and resolute retelling of the fateful tale of the Pequod, a ship in pursuit of a vengeful white whale. The libretto, by Gene Scheer, hits the book’s main conflicts without losing track of the action. The score, by Jake Heggie, is graceful and propulsive. The opera’s ending is certain and clear.

    It’s probably fair to say that more people know the story of the white whale from parodies or synopses than from reading “Moby Dick.” But an adaptation is not just a summary of the book’s major events. A society obsessed with efficiencies can be overly focused on directness.

    Skillful though it is, the opera, which had its premiere in Houston in 2010, has a kind of scrubbed and airless storytelling that leaves the singularity of the novel behind. This is the sort of adaptation that audiences have long responded to — a simplification of the book’s billowy structure to emphasize its plot. But can a tidy adaptation truly represent this unruly book, with its dramas born of endless uncertainties? Or is the purpose of adaptation something different?

    A composer decides what aspects of the narrative can be told through music, while a librettist shapes the story through words that can be thrown out into the air by way of song. An aria reveals a character’s singularity and ambition. Characters sing them to announce what they want and what lengths they must pursue to get it. Each creative turn adds distance from the book.

    Certainly, there are advantages to adapting a work as well known as “Moby Dick.” There’s a beginning, middle and end that have met the approval of readers, and that can serve as the ballast for any number of creative reinterpretations. There’s less risk for a production, too. While Melville’s original publisher, Harper and Brothers, considered the book a commercial failure when it came out, few works compare in influence and longevity.

    There are also distinct disadvantages to adapting “Moby Dick.” Melville’s language can be difficult. The book has hundreds of pages of exposition. And much of the story’s foreshadowing comes through subtle cues, metaphors and allegories.

    The novel, at its heart, is a moral tale about how people deal with what they most fear, how they confront what they despise, and how they make sense of defeat. These are abstract agonies played out through a cast of characters who don’t really evolve. Instead, they press on becoming archetypes of unrealized ambitions. Though Ishmael (called Greenhorn in Scheer and Heggie’s opera) narrates the book, Captain Ahab (the tenor Brandon Jovanovich at the Met) is the star of the opera, an apt, dramatic choice: He is the novel’s most complex and developed character.

    In the novel, Ahab is most tender, though inconsistently, in his interactions with Pip, a 14-year-old cabin boy. In the opera, Pip’s story serves as the turning point that reveals Ahab’s heartlessness. Pip is an innocent, and his naïveté stands in contrast to the sailors’ confidence. His survival is in the hands of the crew, and his presence raises the stakes of the voyage. After a mishap, Pip (sung by the soprano Janai Brugger) suffers immensely; his resulting fear is a harbinger of troubles to come. Pip’s transformational moment occurs earlier in Scheer’s telling than in the book, a dramaturgical choice that speeds the narrative along, while keeping all the novel’s essential notes.

    Setting Melville’s thorough and moody prose to music seems a natural. Its lyrical quality invites music that reaches for harmonies: The text is full of open vowel sounds, made when the tongue doesn’t obstruct the flow of air. That can be useful to singers when they harmonize, especially in choral performances.

    Melville’s diction can also be oratorical, organized with the driving energy of a sermon. In “The Lee Shore,” a funerary chapter offered as testimony for a sailor who will be lost to the sea, the narrator weighs the disappointment of a life unfulfilled against the finality of death, “Better is it to perish in that howling infinite, than be ingloriously dashed upon the lee, even if that were safety!”

    There’s a natural lyricism in Melville’s sentences, even as the narration drifts between pessimism and optimism. Often, he attempts to name feelings that reside someplace deep and unseen. He does this by embracing rhythmic patterns used in poetry. Consider the narrator’s need to reckon with “a damp, drizzly November in my soul.” This frequently cited passage in the book’s opening paragraph carries a pattern of stress and intonation.

    But Melville’s sentences are often lengthy as they wind through multiple ideas. This makes them difficult to sing. Scheer’s libretto is forthright in its characterizations. Its lines, many lifted right from the book, are deceptively simple, written with great control. Some are as short as one or two words. Through the muscular interpretation of the chorus, these monosyllabic utterances — “Aye!,” “Ding!” — become brief, euphonious hollers.

    Not all adaptations of “Moby Dick” are faithful to the disposition of the novel. The British composer Robert Longden and the librettist Hereward Kaye created a bawdy musical about the staging of “Moby Dick” by the girls of St. Godley’s Academy for Young Ladies. (It opened on the West End in 1992, was widely panned, and closed after just a few months.) The performance artist Laurie Anderson created an avant-garde version of “Moby Dick” in 1999, called “Songs and Stories From Moby Dick.” The book is really about “enormous heads,” she says in the show — specifically Melville’s, which was “full of theories and secrets and stories,” and the whale’s, which was monstrously large.

    Some more conventional adaptations could be interpreted as acts of devotion to Melville’s messiness. Dave Malloy’s 2019 version, performed at A.R.T. in Cambridge, Mass., reckoned with the eclectic style of each chapter. It also explores the ways gender and race create their own subplots in the narrative. Another recent adaptation, created by the English actor Sebastian Armesto and simple8, a production company that specializes in minimalist productions, told many of the story’s crucial moments through sea shanties.

    But perhaps it’s a bad idea to assume that a retelling of “Moby Dick” should do anything other than honor the adapting artists’ commitment to it. At best, their vision will just as discernible as Melville’s is. At worst, one could always pick up the book.

    One thing that distinguishes Heggie and Scheer’s adaptation is the frequency with which it has been performed (a distinction that is also rare for a contemporary opera). Before coming to the Met, it was performed by opera companies in Salt Lake City, Los Angeles, Dallas, San Francisco and more. You could argue that it has become canonical, despite being only 15 years old.

    Are there too many adaptations of Moby Dick? Probably not. Hard times breed bitter men like Captain Ahab, and there is always another one filled to his hat’s brim with grievances; always another who feels more than justified in his anger; always another who is ready to drown those around him in his misery.

    Wendy S. Walters is a professor of nonfiction in the writing program at the School of the Arts at Columbia University.



    Source link

  • For Gene Hackman, a Jarring End to a Quiet, Art-Filled Life in Santa Fe

    For Gene Hackman, a Jarring End to a Quiet, Art-Filled Life in Santa Fe


    Years after Gene Hackman retired from acting, he was at dinner with a friend in New Mexico who wanted to know how actors were able to cry on cue.

    “He put his head down at the table for about 30 seconds and raised his head up and there are tears coming down,” the friend, Doug Lanham, recalled. “He looked at me and goes, ‘How do you like that?’”

    After a long career in movies that won him two Oscars and the admiration of generations of film lovers, Mr. Hackman left Hollywood behind for Santa Fe, where he spent his final decades enjoying its striking scenery, trying his hand at painting and writing novels while living what appeared to be a quiet but full life with his wife, Betsy Arakawa.

    He played an active role in the city’s civic and social life during his early years there before slowing down and growing a bit more reclusive as he entered his late 80s and then his 90s, friends said. Some had been expecting to get word of his death from Ms. Arakawa one of these days.

    So it was shocking for them to learn this week that Mr. Hackman, 95, had been found dead in the mud room of his home in Santa Fe and that Ms. Arakawa, 65, had been found dead in a bathroom near an open prescription bottle and scattered pills. One of the couple’s dogs, a German shepherd, was found dead in a nearby closet.

    The Santa Fe County Sheriff’s Office, which is investigating after finding the bodies on Wednesday, said that there were no signs of foul play but that it could not yet say what had caused their deaths.

    It was a jarring end to Mr. Hackman’s post-Hollywood life, one characterized by a deep involvement in Santa Fe’s artistic community as a painter and writer and later by a more insular life with Ms. Arakawa and their dogs in a secluded neighborhood looking out onto the mountains. The couple’s two-story home is ensconced in trees, providing privacy from nearby homes and the winding neighborhood roads.

    Today, some of his paintings — including landscapes and portraits and a brightly colored scene of women lounging by blue and green waves — can be seen in a Santa Fe restaurant called Jinja, which he and Ms. Arakawa had invested in.

    He served on the board of the Georgia O’Keeffe Museum, one of Santa Fe’s main cultural destinations, for about seven years, and called the museum a reminder “of the striking beauty of this land and the way she saw it” when he spoke at the museum’s opening in 1997.

    “In the 10 years I’ve lived here, I’ve been taken with the excitement and indomitable spirit of this place,” Mr. Hackman said at the opening, according to an account in the Santa Fe New Mexican.

    Mr. Hackman’s life in Santa Fe began in the late 1980s, shortly after his first marriage ended in divorce. He was drawn to the area after filming there, and he eventually became a part of the city’s vibrant artistic circles.

    “It was wonderful camaraderie,” said Susan Contreras, a local painter whose husband, Elias Rivera, would host artists, including Mr. Hackman, for painting and drawing sessions in his studio.

    He had distinct views about how things should look. An Architectural Digest article from 1990 about a property he bought near Santa Fe described how he worked to demolish the existing home and commissioned architects to design a new one for him and Ms. Arakawa. “He occasionally mixed colors on his own palette to show the workmen precisely what he wanted,” the article said

    The couple married in 1991, the same year she graduated with a master’s degree in liberal arts from St. John’s College in New Mexico.

    Locals grew used to seeing Mr. Hackman around town, Mr. Lanham said, though there would sometimes be paparazzi or the odd person following him around a grocery store.

    With his friends, he tended to be self-effacing and open to any questions about his past, they said. One longtime friend, Tom Allin, said Mr. Hackman would tell a story about a time before movie stardom, when he got a job that required him to dress up as a toy soldier outside F.A.O. Schwarz in New York around Christmastime.

    He was standing on the sidewalk in costume — red-circled cheeks and all — when his old drill sergeant from the Marine Corps passed by. Mr. Hackman tried to dodge the sergeant, as the story goes, but he was recognized and his old drill sergeant barked, “Hackman! I knew you’d never amount” to anything.

    He undoubtedly did amount to something. But after a four-decade career he quietly withdrew from acting, telling an interviewer in 2008 that he did not want to risk “going out on a real sour note.”

    As his Hollywood years faded, Mr. Hackman focused more of his energy on writing, teaming up with a friend, Daniel Lenihan, to write novels. The pair wrote several books together, including a Civil War novel about a Union officer’s escape from a Confederate prison camp and a 19th-century sea adventure novel.

    He was pretty intense about everything he did, and he liked to do it right,” Mr. Lenihan said.

    Mr. Lenihan’s wife, Barbara Lenihan, started a home décor business in Santa Fe with Ms. Arakawa, offering designer bedding and other kinds of textiles.

    Friends described Ms. Arakawa as Mr. Hackman’s fierce protector, especially as he grew older. In 2012, after Mr. Hackman was struck by a car while biking, Ms. Arakawa dressed up as a nurse to get in and out of a hospital without attracting the attention of photographers, Mr. Allin recalled.

    He said the couple had a hand signal that Mr. Hackman would use if he needed to get out of an uncomfortable conversation with a fan. Ms. Arakawa was intent on keeping him eating healthy, and his friends recalled him sneaking the occasional muffin or cinnamon bun when she was not there.

    “He said many times that he would have been dead without Betsy,” Mr. Allin said, who noted that in recent years he typically communicated with Mr. Hackman through his wife because he did not think Mr. Hackman had a cellphone or email address.

    After Mr. Allin and his wife moved out of New Mexico, Mr. Hackman gave them a painting he made of a pinyon pine among some shrubs in front of a pastel purple mountain range. “Tesuque’s calling,” Mr. Hackman wrote, referring to his old neighborhood north of Santa Fe.

    He was urging his friends to return.

    Kirsten Noyes contributed research.



    Source link

  • Gene Hackman, a Life in Pictures

    Gene Hackman, a Life in Pictures


    Gene Hackman, a celebrated actor whose death at 95 was announced on Thursday, stood out in Hollywood for his ability not to stand out.

    Not until he was 42 did he make his star turn, winning the Oscar for best actor for playing a gruff narcotics detective in “The French Connection.” But at that point he already had more than 30 television and film credits and a reputation for charming intensity that would stay with him throughout his career.

    A tall man with thinning hair and a deep voice that was befitting a former Marine, he is easily remembered for distinctive mustaches and tweed jackets. Yet he was equally convincing in roles as a paranoid communications expert, an archnemesis of a superhero, a big-hearted basketball coach, a sinister sheriff and an eccentric patriarch of a family of troubled geniuses.

    And if he seemed to some to have appeared out of nowhere in the 1970s as a fully formed star, he disappeared just as abruptly, doing one final film in 2004 and then walking away without any formal declaration that he had retired. He spent his remaining years in Santa Fe, N.M., painting and sculpting and staying out of the spotlight.

    He was Hollywood’s Everyman, but had a career — and a life — that few could even attempt to recreate.

    Credit…Everett Collection

    Mr. Hackman made an impression on Warren Beatty in 1964 despite a small part in the film “Lilith.” Mr. Beatty subsequently brought Mr. Hackman along for “Bonnie and Clyde” (1967), in which he managed to thrive in a cast that included, from left, Estelle Parsons, Mr. Beatty, Faye Dunaway and Michael J. Pollard. The performance earned Mr. Hackman an Oscar nomination for best supporting actor.

    Credit…Associated Press

    Mr. Hackman celebrating his first Oscar, for best actor, for “The French Connection,” which won best picture; alongside Jane Fonda, who won best actress for “Klute,” in 1972. They were flanked by Philip D’Antoni, a producer of “The French Connection,” and William Friedkin, its director, who also won an Oscar.

    Credit…Bob Self/Associated Press

    Mr. Hackman had a brief stint in professional auto racing in the 1980s, competing in a few events, but ultimately decided he wasn’t a fit for the sport. “I think that, to be really good, you have to be extremely selfish, which is probably true in a lot of professions, including acting,” he told The Los Angeles Times. “So I could maybe fulfill that part of it. But I think you need a tougher personality than I have. You have to be harder than I’m capable of.”

    Credit…James Hamilton/Touchstone Pictures, via The Kobal Collection

    Mr. Hackman saved one of his most memorable roles for his final years of acting, bringing an irreverence to “The Royal Tenenbaums” in 2001. He stood out in an ensemble cast that included Anjelica Huston, Gwyneth Paltrow, Ben Stiller, Luke Wilson, Owen Wilson and Bill Murray. Mr. Hackman’s antics with his grandsons showed a playful side that was sometimes missing from his earlier films. He also delivered showstopping lines like: “Hell of a damn grave. Wish it were mine.”



    Source link

  • Teenage Smoking Can Lead To Genetic Damage, Can Impact Future Kids: Study

    Teenage Smoking Can Lead To Genetic Damage, Can Impact Future Kids: Study


    Researchers from the UK-based University of Southampton and the University of Bergen in Norway investigated the epigenetic profiles of 875 people, aged 7 to 50, and the smoking behaviours of their fathers.

    They found epigenetic changes at 19 sites mapped to 14 genes in the children of fathers who smoked before the age of 15. 

    These changes in the way DNA is packaged in cells (methylation) regulate gene expression (switching them on and off) and are associated with asthma, obesity and wheezing.

    “Changes in epigenetic markers were much more pronounced in children whose fathers started smoking during puberty than those whose fathers had started smoking at any time before conception,” said Dr. Negusse Kitaba, Research Fellow at the University of Southampton. 

    “Early puberty may represent a critical window of physiological changes in boys. This is when the stem cells are being established which will make sperm for the rest of their lives,”Kitaba added.

    According to Dr Gerd Toril Morkve Knudsen from the University of Bergen and co-lead author of the study, 16 of the 19 markers associated with father’s teenage smoking had not previously been linked to maternal or personal smoking. 

    This suggests these new methylation biomarkers may be unique to children whose fathers have been exposed to smoking in early puberty.

    “Our studies have shown that the health of future generations depends on the actions and decisions made by young people today long before they are parents in particular for boys in early puberty and mothers/grandmothers both pre-pregnancy and during pregnancy,” said Professor Cecilie Svanes from the University of Bergen.

    The new findings have significant implications for public health. They suggest a failure to address harmful exposures in young teenagers today could damage the respiratory health of future generations, further entrenching health inequalities for decades to come.



    Source link