Tag: Physical Health

  • 5 exercising mistakes that can increase anxiety – Times of India

    5 exercising mistakes that can increase anxiety – Times of India


    We all know that regular exercise can help us avoid illnesses and achieve a perfect body and mind. Yet when it comes to setting an exercise routine or following the right practices, we tend to make certain mistakes that can leave us anxious. Weight loss is a long and arduous journey, and cannot be achieved with workouts alone. It’s important not to overdo exercise and take care of nutrition in order to achieve the desired results.

    Here are 5 exercising mistakes that can cause anxiety:

    2

    Overtraining

    If you want a good physique and to look fit and attractive, you should follow a routine and stick to it.Pushing yourself to the gym seven days a week won’t benefit you. It will only harm your body. Pushing yourself beyond limits is not the smart thing to do; it can impact your physical and mental health. One should always rest, as it will not only help muscles recover but also prevent burnout. A study published in the Journal of Sports Sciences found that overtraining negatively impacts the autonomic nervous system, which can increase symptoms of anxiety and depression.

    Not taking proper diet

    In our busy and occupied schedule, we often forget to take care of our health and may skip having lunch or dinner just because we don’t feel like it. If you are exercising, it is extremely important to eat a proper diet and nutritious food; otherwise, it can harm your mental health, lead to fatigue, and exhaust you emotionally and physically, which can lead to anxiety. A study published in Frontiers in Psychology in 2018 found that low diet intake was linked to increased anxiety levels.

    3

    Not stretching

    If you go to the gym or exercise a lot, it is extremely important to stretch before you start training your body. If you don’t do your stretching pre- or post-workout, it can make your body stiff and cause body pain, muscle cramps, and headaches. Stretching is very important to keep your body flexible and avoid any physical or emotional burnout. According to the Journal of Physical Therapy Science in 2018, regular stretching exercises improved mental health, reducing symptoms of anxiety and depression.

    Challenging your capacity

    One should always listen to their body; your body is not a robot; it needs rest, food, water, and enough sleep to function properly. Challenging your capacity won’t make you physically fit; when your body gives you signals, it is telling you to slow down, take rest, or it may cause injury. It can create physical and mental stress.

    Not getting enough sleep

    Exercise, gym, and sports are the best ways to keep fit; they will help you increase your stamina and keep you healthy. Many people who are managing the gym and their busy schedule together often can’t get enough sleep. It can be very harmful to your body; it can cause anxiety and fatigue. A 2019 study published in Nature Human Behavior by researchers at the University of California, Berkeley, found that sleep deprivation can significantly increase anxiety levels.

    5 Exercises that will keep you young





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  • Why Mental Health Is A Big Part Of Physical Health?

    Why Mental Health Is A Big Part Of Physical Health?


    In the last couple of decades, there has been a big focus on physical health. It has now become common for apartment buildings to have fitness centers. Many large corporate offices will also have games and fitness centers. Many of us now take great care not to consume that much sugar, cut back on junk food and in general, try to lead a healthy lifestyle. 

    However, mental health plays a big role in physical health as well as shared by Deepak Sahni, Founder of Healthians.

    Data indicates that chronic stress is increasing among today’s youth. GenZ and MIllennials in particular are much more stressed out compared to any other generation. A survey conducted by India’s largest insurer revealed that 77% of Indians display at least one sign of stress on a regular basis. The report also showed that levels of workplace wellness have gone down over the past few years, particularly among GenZ and women. 

    Countless studies show that mental and physical health are closely linked. Mental stress can lead to a higher risk for ailments such as heart disease, high blood pressure and diabetes. 

    Why is Stress Increasing?

    Undoubtedly, the COVID-19 pandemic has played a huge role in rising levels of stress among people. 

    First of all, the pandemic forced people to stay indoors and miss out on the socialization that is vital to good mental health. 

    Secondly, the impact on the economy was such that many people were laid off and job insecurity increased. This has ended up making our workplaces highly competitive. As a result, many youngsters feel obligated to prove themselves at the workplace not because they want to do well but because they fear losing their job.

    At the same time, people from the younger generation also face other sources of stress. Social media usage is at an all-time high among younger generations. Data shows that GenZ spends an average of 45 minutes per day on Instagram – that’s a good 6 hours every week. 

    Research has shown that social media negatively affects the mental health of people. Why is that? Social media paints a false picture of someone’s life. When we see photos from a friend or an acquaintance’s vacation, night out or a family celebration, we only see the positive moments from their life. This can make us feel like our life is not as interesting or fun, whereas the truth is that everybody goes through problems. 

    But social media makes it possible for people to present a picture perfect version of their life, even though that may not be the whole truth.

    How can you protect your mental health?

    Firstly, identify the sources of stress in your life. Is it a result of physical ailments? If that is the case, you should work on improving your physical health. There is well established research that physical health and mental health both go hand-in-hand. When one improves, usually the other does as well.

    If it is due to emotional stress, don’t shame yourself. One of the biggest reasons people suffer in silence is because they are afraid of appearing weak or vulnerable. There is no harm in admitting that you are going through a tough time, whether it is at work or at home or personally. When you recognise the source of the problem, you will automatically find ways to resolve it.

    These days, therapy is a lot more accessible and is not considered as taboo as it used to be. There are also many free online resources for understanding emotions and learning how to deal with stress.

    If overwork is the source of your stress, then learn how to say no. At the same time, workplaces also need to make it easier for employees to come out and voice their concerns.

    Nothing is as important as your health

    Research shows that our brains are highly malleable, no matter what age we’re at. That’s why it’s never too late to start improving upon your mental and emotional health. 



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  • World Health Day 2024: How Are Physical And Mental Health Connected? Expert Shares Dos & Donts For Optimal Wellbeing

    World Health Day 2024: How Are Physical And Mental Health Connected? Expert Shares Dos & Donts For Optimal Wellbeing


    We often overlook our mental health because it’s not as readily visible as physical ailments. However, the reality is that it profoundly impacts our physical well-being. Take chronic stress, for example, it is a mental health issue that can wreak havoc on your body. It weakens your immune system, making you more vulnerable to illnesses. Moreover, it can lead to unhealthy habits such as poor sleep, overeating, or substance abuse, all of which take a toll on your physical health. 

    Conversely, physical health problems can significantly affect your mental state. For instance, a lack of exercise, important for physical health, can contribute to low mood and fatigue.

    Steps to take to maintain your overall well-being

    So, what can we do to maintain overall health? According to Dr Yogesh Gupta, Sr. Consultant Physician, Sterling Hospitals, Gurukul, “Nowadays, many people with sedentary jobs spend prolonged periods sitting. They must aim for at least 30 minutes of moderate-intensity exercise most days of the week. Exercise releases endorphins, natural mood elevators, and enhances sleep quality. Fueling your body right by consuming a balanced diet rich in fruits, vegetables, whole grains, and lean protein provides the energy needed for both physical and mental functions.”

    Dr Yogesh further adds, “Prioritizing sleep is also essential. Aim for 7-8 hours of quality sleep each night, as it is crucial for physical and mental repair. Moreover, practising mindfulness through relaxation techniques like deep breathing or meditation can help manage stress, a significant contributor to both physical and mental health issues.”

    Furthermore, connecting with others is vital for mental well-being. Cultivate strong relationships with friends and family, and don’t hesitate to seek professional help if needed. Social support can make a significant difference in navigating mental health challenges.

    Dos and Don’ts for Optimal Health

    It’s very important to listen to your body. Pay attention to aches, pains, fatigue, or changes in mood. These can be early signs of a physical or mental health issue. Here are some do’s and don’ts listed by Dr Yogesh, to follow for optical healthcare and wellbeing:

    Do:

    – Schedule regular check-ups with your doctor. Preventive care is key to identifying potential health issues early on.

    – Learn healthy coping mechanisms for stress. Find activities you enjoy, like reading, spending time in nature, or listening to music.

    – Challenge negative thoughts. Cognitive-behavioural therapy (CBT) can be a helpful tool for managing negative thought patterns.

    Don’t:

    – Ignore your mental health. If you’re struggling, seek professional help.

    – Compare yourself to others. Focus on your progress and celebrate your achievements.

    – Isolate yourself. Social connection is essential for overall well-being.

    – Get adequate sleep, it helps your body function properly.



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  • Smartphones’ effect on kids under 10 go beyond eyes, say doctors – Times of India

    Smartphones’ effect on kids under 10 go beyond eyes, say doctors – Times of India



    NEW DELHI: Smartphone addiction among children under the age of 10, is known to be detrimental for the eyes. However, doctors on Saturday warned that spending excessive time on the device may worsen physical health and cause a host of behavioural issues.
    According to the World Health Organization (WHO) guidelines, children under five must spend less time watching screens.While the UN health body does not recommend screen time for infants and 1-year-old, those aged 2 years should not be exposed for more than an hour.
    However, “even toddlers as young as one and a half years old are being handed smartphones by their parents,” Dr Rajiv Uttam, Director, Paediatric Pulmonology, Critical Care Paediatrics (PICU), Paediatric Care, Medanta The Medicity, Gurugram, told IANS.
    The doctor noted that illnesses such as “diarrhoea, fever, and other health issues are observed in children who spend excessive time on their devices”.
    Several studies have shown the negative impact of smartphone use on the eye. Prolonged use of smartphones in children has been linked with vision impairment, and dry eyes among others.
    Dr Vikas Taneja, Consultant Paediatrics, Manipal Hospital, Dwarka explained that this is majorly due to radiation, as the children use their mobile phones at a very close distance.
    “Children can present with excessive eye strain, which can lead to redness of the eyes and excessive itching. This can lead to frequent rubbing and watering. The strain in the eyes can lead to headaches, and their sleep might get disturbed. Excessive mobile phone use can also affect the muscles of the eye,” he told IANS.
    This sleep loss can, further, lead to a lot of anxiety and depression. Usually, such children tend to be alone, have low self-esteem, become excessively irritable, have a lot of aggression and behavioural changes, and may throw tantrums.
    Rajiv said that overuse often leads to a detachment from the real world, and the children are likely to display symptoms akin to virtual autism.
    “Habitual smartphone use during meals also contributes to poor eating habits, obesity, and related health issues such as high blood pressure and sugar levels ultimately leading small kids to pre-diabetic stage.”
    Importantly, the visual impairments and attention deficits further compound these concerns, often remaining unnoticed until academic performance suffers, the doctor said.
    To mitigate these risks, the health experts advised parents to prioritise quality time with their children, encourage healthy eating habits, and limit screen time per day. Furthermore, balancing technology with outdoor activities and nutritious meals is crucial in fostering holistic child development.





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  • Silent epidemic of loneliness cisis grips America – SUCH TV

    Silent epidemic of loneliness cisis grips America – SUCH TV



    Loneliness has become a serious issue in the United States, causing significant harm to people’s mental and physical health.

    The problem has been labelled an epidemic by the US Surgeon General, Dr Vivek Murthy, as it continues to affect many lives across the nation, according to the USA Today.

    Loneliness isn’t just about feeling sad and alone; it’s a deep sense of lacking the connections that people need in their lives. Dr Murthy highlighted that it affects individuals in various ways, often triggered by trauma, illness, or the increasing reliance on technology, which sometimes replaces genuine human interactions.

    The situation has worsened, especially during the COVID-19 pandemic. Older adults have felt increasingly isolated, but loneliness isn’t exclusive to them – it affects people of all ages. This feeling of social disconnection isn’t just an emotional issue; it’s a significant health concern. It’s been linked to heart disease, stroke, and mental health problems like depression and anxiety.

    The impact of loneliness on health is alarming. An advisory report published by the US Surgeon General shows that being alone can increase the risk of premature death significantly, almost equivalent to smoking a considerable number of cigarettes daily.

    Lonely individuals are also less likely to take care of themselves properly, neglecting preventive care and healthy lifestyle habits, according to a Harvard study.

    Addressing loneliness requires action both on an individual level and within communities. Experts suggest reaching out to someone regularly, dedicating time to help others, and reducing reliance on devices for social interactions. But it’s not just about personal efforts. Schools, workplaces, and healthcare systems need to adopt strategies that actively combat loneliness.

    To tackle this loneliness epidemic effectively, a collective effort from various sectors of society is crucial.

    Building genuine connections and creating supportive environments will be vital in addressing this growing concern, fostering a society where people feel valued, connected, and supported.



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  • World Mental Health Day: Expert Shares How Stress Can Impact Physical Health

    World Mental Health Day: Expert Shares How Stress Can Impact Physical Health


    In today’s fast-paced world, stress has become an unavoidable companion in our daily lives. From the demands of work and personal responsibilities to the constant barrage of information in the digital age, stressors seem to lurk around every corner. While stress itself is a natural response to challenging situations, its persistent presence can take a significant toll on our physical health.

    Mounting scientific evidence has unveiled a profound connection between chronic stress and a wide range of physical health issues. From cardiovascular problems to weakened immune systems, stress can be the silent saboteur of our well-being. In this article, we delve into the multifaceted ways in which stress can impact our bodies and why it’s crucial to address this often underestimated menace.

    Dr Dinika Anand, Clinical Psychologist, BLK-Max Super Speciality Hospital, New Delhi, shares how stress can impact our physical health. 

    Also read: World Mental Health Day 2023: How Can Relationships Affect Mental Health? Expert Explains

    How Can Mental Stress Affect The Body’s Immune System?

    Dr Anand explains, “Our mind and body are not two separate entities, and thus to even imagine that the experience of stress – whether physical or psychological – will not imprint on the mind/ body is bizarre.”

    “Psychological stress impacts our physical, psychological functioning and experience. Greater proneness to injury, sickness, falls, infections, etc has been documented to an extent that we have an entire discipline dedicated to psychoneuroimmunology — exploring the connections between psychology, neurology, and immunology,” Dr Anand further explained. 

    Can Stress Contribute To Weight Gain Or Obesity?

    “Stress impacts our lifestyle – food habits, sleep patterns, movement routines, mood, etc. A stressed person reaching out for comfort food will easily put on weight while another one who is dealing with loss of appetite due to stress may find themselves skipping meals and losing weight,” Dr Anand said.  

    How Does Stress Influence Sleep Patterns And What Are The Consequences Of Sleep Disturbances On Physical Health?

    “Increased stress will leave a negative impact on both the quality and quantity of sleep. Difficulty falling asleep, frequently waking up in the night, rumination and negative thinking at bedtime, and bad dreams are all common occurrences for people who are dealing with short-term or long-term stress. Poor sleep then percolates into dysfunctionality in the subsequent day which can further increase the stress,” Dr Anand said. 

    Strategies And Lifestyle Changes That Can Help Mitigate The Effects Of Stress?

    Dr Anand shares, “At the baseline, it is crucial for us to change our attitude towards stress. By understanding that we have to manage the stress that our life brings instead of trying to eliminate it. This would enable us to create practices and strategies that can help us take care of ourselves and our stress levels in day-to-day life so that stress does not increase and also give us some tools to manage those periods when there is acute stress and when life throws something at us, which involves a Stressful life experience.”



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  • Sleep-Liver Connection: How Sleep Apnea Impacts Liver Health? Expert Shares Ways For Effective Treatment

    Sleep-Liver Connection: How Sleep Apnea Impacts Liver Health? Expert Shares Ways For Effective Treatment


    Sleep apnea is a condition characterized by interrupted breathing during sleep, leading to frequent awakenings and reduction in sleep quality. Consistent sleep interruptions can harm physical health, weakening the immune system and increasing vulnerability to illnesses.

    In an exclusive interview with Zee News English, Dr Randeep Guleria, Chairman, Institute of Internal Medicine & Respiratory and Sleep Medicine at Medanta, and Former Director & CEO, AIIMS, New Delhi talks about the growing link between sleep apnea and non-alcoholic fatty liver disease i.e. how your sleep can affect your liver health.

    Connection Between Sleep Apnea and Non-Alcoholic Fatty Liver Disease

    “In addition to its adverse effects on overall health, sleep apnea can also contribute to the development of Non-alcoholic fatty liver disease (NAFLD), a condition commonly observed in overweight or obese individuals. Excess weight can contribute to Obstructive sleep apnea (OSA) by narrowing the airway, while also promoting insulin resistance and fat deposition in the liver, exacerbating fatty liver disease,” says Dr Guleria.

    According to a report, “OSA is associated with an increase in liver enzyme concentrations in 35% of obese individuals. This connection highlights the importance of addressing obesity through lifestyle changes and medical interventions to improve both sleep and liver health,” quotes Dr Guleria.

    Impact of Sleep Apnea on Physical Health

    “With the frenetic lifestyles that people have today, health has taken a backseat for many due to paucity of time, leading to lifestyle diseases such as obesity.”

    Dr Randeep Guleria comments, “The typical approach to treat patients with Non-alcoholic fatty liver disease and Obstructive sleep apnea has centered on addressing concurrent conditions such as obesity, diabetes mellitus, hyperlipemia and cardiovascular disease. Weight loss has demonstrated its effectiveness in enhancing insulin sensitivity, and in some instances, it has led to the resolution of nonalcoholic steatohepatitis (NASH).” 

    “Moreover, insulin resistance (IR) emerges as a common denominator in many cases of  Non-alcoholic fatty liver disease and Obstructive sleep apnea.”

    4 Ways Sleep Apnea and Non-Alcoholic Fatty Liver Disease can be managed

    Let’s look at some of the approaches that Dr Randeep Guleria has shared which have been advocated for managing both Obstructive sleep apnea and  Non-alcoholic fatty liver disease simultaneously:

    Lifestyle adjustments and weight reduction

    When it comes to managing OSA and NAFLD, lifestyle interventions should be the first line of treatment. A key component of managing NAFLD is adopting a balanced, low-fat diet, incorporating regular exercise to the schedule, and reducing the intake of saturated and trans fats.

    Continuous positive airway pressure (CPAP) therapy

    For individuals suffering from both Non-alcoholic fatty liver disease and Obstructive sleep apnea, CPAP therapy is a valuable treatment. The CPAP machine sends air under pressure through the tube into the mask, where it imparts positive pressure to the upper airways. This essentially acts as “splints” and keeps the upper airways open and prevents them from collapsing. It is also helpful in reducing elevated biochemical and liver enzyme levels in people with both Non-alcoholic fatty liver disease and Obstructive sleep apnea.

    Insulin Sensitizer drug

    In cases where lifestyle changes and CPAP therapy are insufficient, other treatment modalities may be considered. One such option can be an insulin sensitizer drug which aims to enhance the body’s response to insulin, thereby reducing blood sugar levels and potentially mitigating the impact of insulin resistance on NAFLD.

    Bariatric surgery

    Bariatric surgery, primarily used for morbidly obese patients, can also improve conditions associated with Obstructive sleep apnea (OSA) and Non-alcoholic fatty liver disease (NAFLD). This treatment option can be an alternative for severe and complicated obesity.

    “The effectiveness, performance and general health of a person can all be enhanced by getting adequate sleep. The easiest approach to determine whether you are getting enough sleep is by feeling refreshed when you wake up,” concludes Dr Randeep Guleria.



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  • Dancing Beyond Cardio: 5 Reasons Why Dance Enhances Physical Fitness And Mental Well-Being

    Dancing Beyond Cardio: 5 Reasons Why Dance Enhances Physical Fitness And Mental Well-Being


    Dancing is more than just rhythmic movements to music; it’s a transformative activity that seamlessly integrates physical fitness with creative expression. 

    Beyond its evident allure, dancing offers a range of health benefits that go beyond traditional forms of exercise. 

    5 Ways Dancing Boosts Your Physical and Mental Health

    Here’s a list of incredible ways dancing can boost both physical fitness and mental well-being.

    1. Cardiovascular Endurance

    Dancing gets your heart pumping, promoting cardiovascular health. Whether it’s salsa, hip-hop, or ballroom, the continuous movement in dance routines elevates your heart rate, improving overall endurance and stamina.

    2. Flexibility and Balance

    The diverse movements in dancing enhance flexibility and balance. The various dance styles involve stretching, bending, and maintaining postures, resulting in increased flexibility and better balance, reducing the risk of injuries.

    3. Calorie Burn and Weight Management

    Dancing is a calorie-burning powerhouse. Depending on the intensity and style, you can torch a significant number of calories, aiding in weight management and toning muscles. It’s an enjoyable way to shed those extra pounds.

    4. Stress Reduction and Mental Health

    Dancing has a profound impact on mental well-being. It serves as an effective stress-reliever, promoting the release of endorphins, the body’s natural mood enhancers. Engaging in dance can lift your spirits, reduce anxiety, and improve overall mental clarity.

    5. Boosting Creativity and Self-Expression

    Dancing is an artistic form of self-expression. It encourages creativity as you interpret the music through movement. Whether you’re following choreography or freestyling, dancing lets you unleash your creativity, fostering a sense of accomplishment and fulfillment.

    Incorporating dance into your lifestyle isn’t just about moving to a beat; it’s about embracing a holistic approach to health and well-being. It’s a joyful journey that encompasses physical fitness, mental rejuvenation, and the freedom to express your true self.

    (This article is meant for informational purposes only and must not be considered a substitute for advice provided by qualified medical professionals.)



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  • Ear Health: 7 Yoga Asanas to Improve Hearing

    Ear Health: 7 Yoga Asanas to Improve Hearing


    In a world filled with noise and distractions, our sense of hearing often takes a backseat in our pursuit of physical and mental well-being. However, recent studies have shed light on the powerful connection between yoga and auditory health. Yoga, an ancient practice known for its myriad of physical and mental benefits, can also play a pivotal role in enhancing our hearing abilities.

    While hearing loss is a common concern among people of all ages, incorporating specific yoga asanas into your daily routine can provide a natural and holistic approach to maintaining and improving auditory wellness. Here we have listed seven yoga postures that can help boost your hearing capabilities and overall ear health.

    Matsyasana (Fish Pose):

    Often referred to as the “Fish Pose,” Matsyasana is a beneficial posture for enhancing hearing. This pose involves arching the back and tilting the head backward to create a gentle stretch in the neck and throat. By opening up the throat and neck regions, Matsyasana can improve blood circulation to the ears, thus aiding in auditory function.

    Also read: 7 Mood-Boosting Foods To Make Your Happy And Healthy

    Ustrasana (Camel Pose):

    Ustrasana, or the “Camel Pose,” involves a deep backward bend. This asana stretches the neck and throat, stimulating the thyroid gland, which regulates metabolism and energy. By promoting thyroid health, Ustrasana indirectly supports the overall well-being of your ears.

    Bhramari Pranayama (Humming Bee Breath):

    Bhramari Pranayama, also known as the “Humming Bee Breath,” is a breathing exercise that involves making a low-pitched humming sound during exhalation. Regular practice of this pranayama can stimulate the ear’s internal structures and improve their sensitivity to sound.

    Shanmukhi Mudra (Six-Part Hand Gesture):

    Shanmukhi Mudra is a yogic hand gesture that involves closing all six senses, including the ears. By gently covering your ears with your hands and using your fingers to block external noise, you create a serene environment for your auditory system. Practicing this mudra regularly can help in reducing sensory overload and promoting auditory clarity.

    Viparita Karani (Legs-Up-the-Wall Pose):

    Viparita Karani, or the “Legs-Up-the-Wall Pose,” is an inversion that encourages blood circulation towards the head and neck area. This enhanced circulation can contribute to better oxygenation and nourishment of the auditory system, potentially improving hearing over time.

    Trataka (Candle Gazing):

    Trataka is a meditation technique that involves gazing at a steady flame. While primarily aimed at enhancing concentration and mental clarity, this practice indirectly benefits auditory health by promoting mindfulness and reducing stress, which can contribute to hearing problems.

    Sarvangasana (Shoulder Stand):

    Sarvangasana, or the “Shoulder Stand,” is another inversion that can improve blood flow to the head and neck region. By boosting circulation to the ears, it helps in maintaining the health of the auditory system and may aid in preventing hearing issues.

    Incorporating these yoga asanas and practices into your daily routine can provide a holistic approach to enhancing your auditory health. However, it’s essential to remember that yoga should be practiced mindfully and under the guidance of a qualified instructor, especially if you have pre-existing medical conditions. By nurturing your auditory well-being through yoga, you can embrace the harmony of a balanced and healthier life, where sound is not just heard but truly appreciated.



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  • Basic Blood Test Can Predict Heart And Kidney Risks For People With Diabetes, Study Reveals

    Basic Blood Test Can Predict Heart And Kidney Risks For People With Diabetes, Study Reveals


    An analysis of a clinical trial of more than 2,500 people with type 2 diabetes and kidney disease has found that high levels of four biomarkers in blood tests are strongly predictive for the development of heart and kidney issues, according to the study published in the American Heart Association’s flagship journal Circulation.

    “High levels of certain biomarkers are indicators of heart and kidney complications and may help predict future risk of disease progression,” said lead author James Januzzi from Harvard Medical School, also a cardiologist at the Massachusetts General Hospital.

    People who took canagliflozin, a sodium glucose co-transporter 2 inhibitor (SGLT2 inhibitor), had lower levels of the four biomarkers compared to those who took a placebo over the three-year study period.

    Canagliflozin is a third-line medication to be tried after metformin, a first-line medication for type 2 diabetes.

    Treatment with canagliflozin helped to substantially reduce the risk of hospitalisation for heart failure and other heart complications among patients considered to have the highest risk.

    The researchers analysed biomarker data from the blood samples of 2,627 people to assess the effects of canagliflozin on concentrations of the four biomarkers. Patients were separated into low, medium and high risk categories.

    People at highest risk showed dramatically higher rates of progressive kidney failure and cardiovascular complications throughout the three-year study period.

    The analysis found high concentrations of each biomarker at the beginning of the study were strongly predictive of the severity of the participant’s heart and kidney issues.

    The concentrations of each of the four biomarkers in people taking canagliflozin were lower after one year and three years compared to those taking the placebo.

    After one year, the levels of all biomarkers in participants who took canagliflozin rose 3 per cent to 10 per cent, compared to an increase of 6 per cent to 29 per cent in those who took the placebo.

    “It was reassuring to discover that canagliflozin helped reduce risks the most in people with the highest chances for complications. Future studies are needed to better understand how type 2 diabetes in conjunction with kidney disease develops and progresses so that we may initiate life-saving therapies earlier, before symptoms of heart and kidney disease have occurred.” Januzzi said.



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